Sumbul Sohail, Shaista Rashid, Syed Tariq Ali Adnan.
Impact of tranexamic acid on quality of life in women with heavy menstrual bleeding.
Pak J Surg Jan ;32(1):44-8.

Heavy menstrual bleeding (HMB) is defi ned as excessive menstrual blood loss which interferes with a woman’s physical, social, emotional and/or material quality of life. It can occur alone or in combination with other symptoms. HMB is associated with signifi cant morbidity and any treatment off ered should improve the quality of life rather than focusing on menstrual blood loss. In the early 1990s, it was estimated that at least 60% of women had hysterectomy for heavy menstrual bleeding. Material and methods:Th is open uncontrolled non randomized trial included 200 women aged between 27 and 45 years with an objective diagnosis of heavy menstrual bleeding having no recognizable anatomical pathology were treated with 3.5 – 4 g of tranexamic acid for a period of three months from May 2015-July 2015 att ending OPD in Gynae Unit 2 in Abbasi Shaheed Hospital, Karachi. Th e quality of life and subjectively experienced state of health were assessed with the aid of a questionnaire at baseline and aft er the fi rst and third month of treatment main outcome measures were quality of life of women with HMB and improvement of mean MIQ SCORE aft er treatment. Result:Tranexamic acid oral treatment showed improvement in Mean MIQ scores compared to baseline. Impairment of social activities and household work was greatly reduced by the treatment. Improvement was noted on amount of blood loss which was decreased Adverse eff ects were few and not serious like mild headaches and abdominal discomfort Conclusion:Assessment of quality of life using a validated guestionnaire can become an integral part of clinical trials for cost eff ective analysis on both current and future trials and protocols.

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