Nadia Bano, Shahid Rasool, Ahmed Raza.
Procedural sedation and analgesia for ERCP: A comparative study of the Propofol and Ketamin-Propofol combination (Ketofol).
J Uni Med Dent Coll Jan ;7(1):1-6.

OBJECTIVE: The aim of this study was to find a near ideal drug for procedural sedation and analgesia for patients undergoing ERCP. STUDY DESIGN: A randomized control study was carried out for comparison. SETTING & DURATION: This study was conducted at department of anaesthesia and intensive care, Madinah Teaching Hospital, Faisalabad from August 2014 to July 2015. SAMPLE SIZE: The group under study consisted of 146 ASA I & II status patients undergoing ERCP. METHODS: The patients were randomly divided into two groups A and B. Group A patients were to receive Propofol and Group B patients were to receive Ketamine-Propofol (Ketofol). RESULTS: As compared to Propofol Group (group A), Ketofol group (group B) showed significant hemodynamic stability. The frequency of hypotension was 27.4% in group A as compared to 12.3% in group B. Respiratory drive was maintained in both groups. Requirement for post procedure analgesia was significant in group A being 16.4% as compared to 2.7% in group B. Time of onset and offset were also significantly shorter in group B. CONCLUSION: It is concluded that Ketofol offers stable hemodynamics, adequate sedation and analgesia for patients undergoing ERCP. It also offers quick onset and offset of sedation. So it is a near ideal agent for procedural sedation and analgesia for ERCP.

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