Ejaz Latif, Muhammad Khalid, Mansoor Aaqil, Nazir Ahmad Aasi.
Use of Topical Apraclonidine to Prevent Intraocular Pressure Elevation Following Nd: YAG Laser Posterior Capsulotomy.
Pak J Ophthalmol Jan ;15(3):108-12.

In this randomized prospective study, we have evaluated the effect of 0.5% topical apraclonidine in preventing the IOP rise following Nd:YAG laser posterior capsulotomies. 150 patients including both the aphakics and pseudophakics scheduled for Nd:YAG laser posterior capsulotomy were randomly divided into two groups. In group `A` apraclonidine was instilled one hour before and lust after Nd:YAG capsulotomy. In group `B` placebo drops were similarly instilled. Intraocular pressure, blood pressure and pulse rate were recorded at half hour intervals for the first three hours following Nd:YAG capsulotomy. Eight out of the 75 patients (10.7%) of group `B` developed an IOP rise of more than 10 mmHg from the baseline as compared to none in the apraclonidine-treated group `A`. During the first three hours, IOP reduction of less than 5 mmHg from the baseline was noticed in 6 (8%)patients of group `A`. No systemic adverse reaction of apraclonidine was noticed.

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