Mujeeb Rehman, Aijaz Ahmed Shaikh, Akmal Jamal.
Deep venous thrombosis; mean platelet volume, D-dimer and doppler sonography. patients of surgical wards of Liaquat university hospital.
Professional Med J Jan ;23(01):020-4.

To study mean platelet volume (MPV) in deep venous thrombosis (DVT) as evaluated by D-Dimmer and Doppler sonography. Study Design: Case control study. Place and Duration: Department of Surgery, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from May 2013 to April 2014. Subjects and Methods: A sample of 106 subjects; 50 controls and 53 diagnosed patients of DVT were studied. DVT patients were included according to inclusion and exclusion criteria and after results of Sonography and D-Dimer were available. The Blood samples were collected in bottles containing sodium citrate as anticoagulant. MPV was generated by Sysmex KX 21 hematology analyzer. Informed consent was sought from the volunteer subjects. The Data was analyzed using SPSS version 21.0. Statistically significance was defined at p-value of ≤0.05. Results: Mean platelet volume was elevated in deep venous thrombosis patients which were confirmed by clinical examination, sonography and D-Dimer. MPV was elevated in cases; 10.0±0.7fl compared to controls; 9.55±0.63fl (p=0.001). D-Dimmer was elevated in deep venous thrombosis patients (p=0.0001). Age, gender and platelet counts did not revealed any significant differences between cases and controls (p>0.0.05). Conclusion: The present study reports elevated MPV in patients suffering from deep venous thrombosis and it is concluded that MPV may be considered as a risk factor for DVT.

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