Sajid Hussain, Kashif Ali, Hafiz Muhammad Farhan Rashid, Abrar Hussain Khosa, Aushter Abbas.
Peg tube; prophylaxis of peg tube site infection, comparison of efficacy of cephalexin and co-amoxiclav.
Professional Med J Jan ;23(2):187-92.

To determine the efficacy of Cephalexin and Co-amoxiclave in preventing Peristomal infection after PEG tube placement in head and neck and other cancer patients. Study Design: Prospective, randomized clinical trial. Setting: Internal Medicine Department Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore. Period: February 2009 to September 2009. Material and Methods: A total of 160 patients including both males and females were selected by Non probability purposive sampling. Patients meeting inclusion and exclusion criteria were registered in the study from outpatient department after informed consent. These patients were randomly assigned into two groups. Group A was started on Cephalexin 500mg q6h Per-orally started 24 hrs before the procedure with the 4th dose given one hour before the procedure and continued it as q6h for five days after the procedure. Group B was given Co-amoxiclav 1G Per-orally 12 hrs before the procedure with the second dose of 1G, one hour before the procedure and then same dose advised q12h for five days after PEG tube placement. Results: Male to female ratio in both groups was 2:1 with 63.3% males and 33.8% females. Patients were aged between 19-80years, divided in four age groups with 38.8% falling in age group 50-64 years. Mean age is 52.11+-13.59 years and median age 54 years. The efficacy of Cephalexin and Co-amoxiclave was 84.7% and 78.6% respectively with no significant statistical difference among two groups. Conclusion: We concluded that Cephalexin and Co-amoxiclave were both equally effective in preventing peristomal infection.

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