Amin Fahim, Prof Mohammad Ahmed Azmi, Muhammad Hanif, Anila Qureshi.
Hepatocellular carcinoma; biomarkers: a molecular approach for early detection.
Professional Med J Jan ;23(04):415-21.

Objectives: To determine the expression of miR-92-1 in HCC patients and correlate them with clinicopathological data. Study Design: A Cross sectional study. Place of Study: Samples were collected from Jinnah Postgraduate Medical Center Karachi, Civil Hospital Karachi and Asian Institute of Medical Sciences Hyderabad. Duration of Study: January 2014 to December 2014. Materials and Methods: 150 patients of hepatocellular carcinoma were divided into two groups on the basis of etiologic agent. HCC patients with chronic viral hepatitis B were labeled as group-I, whereas those with chronic viral hepatitis C in group-II, compared with 75 healthy control individuals in group-III. Results: The results showed that miR-92-1 expression was decreased in patients with HCC when compared with controls. Down regulation was seen more pronounced in HCC cases with chronic viral hepatitis C. A significant correlation was found between the expression of miR-92-1 and AFP level 20-200 ng/ml and Child Pugh score B. However no correlation was found between the expression of miR-92-1 and age, gender, fibro scan, tumor distribution, tumor size, tumor metastasis and BCLC stage. Conclusion: miR-92-1 is down regulated in HCC patients with significant correlation with serum AFP level between 20-200 ng/ml.

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