Muhammad Ilyas, Shahana Salim, Rafi-ur Rehman, Neelum Noreen Halimi.
Comparison Of Mean Induction Time And Emergency From Anesthesia Between Sevoflurane And Halothane In Children.
J Med Sci Jun ;24(4):268-72.

Objective: To compare and select the suitable anesthetic agent with rapid induction, smooth rapid recovery, few intra-operative and emergence complications in children. Material and Methods: This randomized control trial study was conducted in Anesthesia department of Khyber Teaching Hospital Peshawar from 1st January 2011 to 31st December 2012. A total of 67 patients aged between 1-12 years of either sex belonging to ASA physical status I were randomly allocated to two groups of 33 and 34 each. Group a (Sevoflurane group) received Sevoflurane and group b (Halothane group) received Halothane as inhalational anesthetic for both induction and maintenance of anesthesia. Time to induction was recorded and statistical analysis of data was done to compare the two agents. Results: The Mean age in Halothane group was 6.8 years and in Sevoflurane group was 6.3 years. Male to female ratio was 1.7:1. Mean induction time with Halothane was 117.6 seconds and with Sevoflurane was 96.3 seconds (p<0.005). Similarly emergence from anesthesia with Sevoflurane was rapid 11.6 minutes earlier than Halothane (p=0.001). Adverse events like excitement, breath holding, secretions, laryngospasm and vomiting were similar and statistically insignificant in Halothane and Sevoflurane groups. Conclusion: Induction and emergence is rapid with Sevoflurane compared to halothane in children.

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