Afra Samad, Munawar Hussain Shah, Rana Khalid Mahmood.
Sodium tungstate; effect on liver of streptozotocin induced diabetic rabbit.
Professional Med J Jan ;23(12):1566-72.

Objectives: To determine the possible morphological effects of sodium tungstate (ST) on liver of streptozotocin (STZ) induced diabetic rabbits. Study design: This prospective study was conducted on 30 rabbits of 30 weeks age. Diabetes was induced in 20 animals by a single intraperitoneal injection of streptozotocin (50 mg/kg). 10 animals were used as control. 10 diabetic rabbits were treated with sodium tungstate (ST) orally and 10 animals were left untreated. Histological examination of liver was performed. Setting: Place: Post graduate medical institute lahore. Duration of study: July 2010 to August 2011. Methods: Blood glucose levels of the rabbits were checked before and after treatment. Histological examination of liver sections of 30 rabbits was performed. Sections were stained with Hematoxylin & Eosin (H & E), Trichrome and Reticulin stains separately. Results were analyzed statistically. Results: Blood glucose levels of diabetic rabbits without Sodium Tungstate therapy were high as compared to normal rabbits and diabetic rabbits treated with sodium tungstate. Histological examination of liver of diabetic rabbits with Sodium Tungstate therapy did not reveal any irregular chromatin pattern or fibrosis. Conclusion: On the basis of histological examination and blood glucose level it is concluded that sodium tungstate is a powerful anti-diabetic agent when administered orally with no morphological changes in liver.

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