Sadaf Bashir, Rubina Mushtaq.
Effect of hyosine butylbromide on first stage of labour in term pregnancy.
Pak Armed Forces Med J Jan ;66(4):485-9.

Objective: To determine the effect of hyosine butyl bromide on mean duration of first stage of labor in term pregnancy by comparing with control group. Study Design: Randomized, double-blind, controlled trial. Place and Duration of Study: Department of obstetrics and gynecology CMH Rawalpindi, from Oct 2012 to Sep 2013. Material and Methods: This was a randomized, double-blind, controlled trial, conducted at department of Gynecology and Obstetrics Combined Military Hospital (CMH) Rawalpindi. Total patients included in the study were 108. Patients were distributed in two groups on the basis of drug given to them. Group-A was labeled as drug Hyoscine Butyl Bromide (HBB) and Group-B was labeled as placebo. Patients selection was done by using a pre defined inclusion and exclusion criteria. Women were admitted with spontaneous and active labour (4cm or more cervical dilation with regular uterine contraction) between 37 to 40 weeks of gestation, with singleton pregnancy, vertex presentation and intact membrane. Laboring mothers were monitored in bed till full dilatation of cervix. The collected data was endorsed on patient’s performa. Data entry and analysis was done by using SPSS 12 and analyzed accordingly to the statistical plan. Results: Mean age of patients in group A was 25.85 ± 3.85 and in group B was 28.07 ± 4.71 years. Mean gestational age in Group-A and group- B was 38.67 ± 1.06 and 38.33 ± 1.09 weeks. Mean duration of first stage of labor in Group-A was 178.98 ± 92.44 and in group-B was 214.74 ± 147.44 minutes. According to p-value mean duration of first stage of labor in both groups was statistically same. i.e. (p-value= 0.135). Conclusion: Use of hyoscine butylbromide allows reduction in the mean duration of first stage of labour as compared to the control group. It not only minimizes the possibility of hastened delivery but also its use can prevent prolonged labour.

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