Inamullah Khan, Salma Naz, Rehmah Sarfraz, Hamid Goreja.
Helicobacter Pylori Antibodies in Hazara Division Population.
Ann Pak Inst Med Sci Jan ;8(1):50-3.

Objective: To evaluate the sensitivity and specificity of a rapid one step test for the qualitative detection of Helicobacter pylori (H. pylori) antibody and screen an asymptomatic Hazara division population for H. pylori seroprevalence. Place & Duration of Study: The study conducted at Inam clinical laboratory, Abbottabad, during the period from 2008 to 2011 Study Design: Analytical study Materials & Methods: It was designed as a blind comparison of a commercial serological test kit for serological diagnosis of H. pylori with a standard biopsy related test referred from various hospitals and private clinics located in Hazara division. We included 70 symptomatic male and female patients, as well as 90 randomly collected sera from asymptomatic patients. Results: The sensitivity of the Acon One step H. pylori Test Device was 59% with a specificity of 89%. Screening of the asymptomatic patient showed an age related increase in antibody prevalence. Conclusion: Because of the limited sensitivity in the investigated population, the use of the Acon One step H. pylori test device alone cannot be recommended for the serological diagnosis of H. pylori infection in the Hazara division population.

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