Muhammad Ishaq, Ghulam Jillani Khan, Sibgha Zulfiqar.
Significance of Type 2 Diabetes Mellitus in the Development of Peripheral Arterial Disease.
Ann Pak Inst Med Sci Jan ;9(3):135-7.

Objective: To determine risk factors for peripheral arterial disease among patients with diabetic mellitus. Study Design: Quasi experimental Study Place and Duration: The study was conducted at the Department of Physiology, Sheikh Zayed Federal Post-graduate Medical Institute, Lahore from November 2008 to December 2010 . Materials and Methods: A total of 150 patients, (age ≥40) with type 2 diabetes mellitus, were selected from the Diabetic Clinic, Cardiology Unit and Biochemistry Department of the Institute. The subjects were equally divided into uncomplicated (n=75) and complicated (n=75) groups. The blood samples of each subject were collected for various blood lipid parameters. The blood pressure of each patient (arm and ankle) was recorded with the help of an sphygmomanometer and a hand held Doppler to calculate his ABI (ankle brachial index). Results: The total and LDL cholesterol in the complicated group were higher than in the uncomplicated group but the triglycerides and HDL cholesterol was in the reverse order. Among these, only the total cholesterol level was statistically significant (P<0.05). It was revealed that the HDL cholesterols level was inversely correlated with PAD. Conclusion: The study confirms that aged and overweight complicated type 2 diabetic patients with low HDL cholesterol level are more vulnerable to develop peripheral arterial disease.

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