Sadaf Nil Durrani, Jasmin Shah, Mudassir Ahmad Khan, Muhammad Rasul Jan.
Hypoadiponectinemia and dyslipidemia in relation to glycemic status in type 2 diabetes and coronary heart disease.
Khyber Med Uni Med J Jan ;6(4):157-62.

Objective: Relationship of adiponectin level with lipid profile and glycemic control was investigated in type 2 diabetic subjects with and without coronary heart disease (CHD). Study design/Methods: This cross-sectional/ analytical study consisted of three groups. Group A consisted of 60 healthy subjects, group B consisted of 60 type 2 diabetic subjects and group C consisted of 60 type 2 diabetic subjects with coronary heart disease. The study participants were selected randomly from tertiary care hospitals and their fasting blood samples were analyzed for serum adiponectin level, triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c). Results: Significantly high adiponectin level was observed in female subjects as compared to male subjects of the studied groups. Type 2 diabetic subjects with and without coronary heart disease showed poor glycemic control and deranged lipid profile. These diseased groups presented with significantly higher FBG, HbA1c, TC and TG (p value <0.05) and significantly lower levels of serum adiponectin and HDL-C (p value <0.001). Adiponectin level showed significant positive association with HDL-C in control group (female: r 0.988; p=<0.01, male: r 0.948; p=<0.01), type 2 diabetic group (female: r 0.908; p=<0.01, male: r 0.860; p=<0.01) and type 2 diabetic group having coronary heart disease (female: 0.775; p=<0.01, male: 0.650; p=<0.01). Serum adiponectin showed significant negative association with TG in control group (female: r -0.515; p=0.01, male: r-0.747; p=<0.01), type 2 diabetic group (female; r -0.790; p=<0.01, male: r -0.747; p=<0.01) and type 2 diabetic group having coronary heart disease (female: r -0.669; p=<0.01, male: r -0.640; p=<0.01). Significant (p value <0.01) negative association of adiponectin was observed with FBG and HbA1c in type 2 diabetic subjects with and without coronary heart disease. Conclusion: Reduced adiponectin is associated with type 2 diabetes mellitus with and without coronary heart disease. However, hypoadiponectinemia in these subjects is also related with un-controlled glycemic status and dyslipidemia.

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