Sobia Ali, Mudassir Ahmad Khan, Mohammad Ali Khan.
Hyperfibrinogenemia in relation to glycemic status and dyslipidemia in type 2 diabetes mellitus and coronary heart disease.
Khyber Med Uni Med J Jan ;7(3):115-9.

OBJECTIVES: To determine plasma fibrinogen level in type 2 diabetic patients with and without coronary heart disease (CHD) and to find relationship of fibrinogen with glycemic control and lipid profile in these patients. METHODS: A cross-sectional / analytical study was performed among the outdoor and indoor patients visiting Khyber Teaching Hospital and Hayatabad Medical Complex, Peshawar, Pakistan. The study consisted of two groups. Group A was comprised of 100 type 2 diabetic patients without CHD and group B was comprised of 100 type 2 diabetic patients with CHD. Biochemical analysis of samples was carried out in the Research laboratory of Biochemistry Department, Khyber Medical College, Peshawar. Plasma fibrinogen level was measured by clotting method and statistical analysis was done on SPSS 19 soft ware. RESULTS: Mean plasma fibrinogen level was 413.44±139.75 mg/dL & 478.63±165.97 mg/dL was observed in group-A & group-B respectively (p<0.05). Mean fasting blood sugar was 175.61±59.13 mg/dL & 213.80±91.62 mg/dL in group-A & group-B respectively (p<0.05). Mean HbA1C in group-A and group-B was 8.308±3.03% & 10.166±3.452% respectively (p<0.05). A strong positive association of fibrinogen was seen with serum triglycerides (p<0.01), total cholesterol (p<0.05) and body mass index (p<0.01). CONCLUSION: Fibrinogen levels are elevated in type 2 diabetic patients with and without coronary heart disease. Moreover, hyperfibrinogenemia is associated with serum cholesterol, serum triglycerides and BMI in these patients.

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