Choudhary Tariq Masood, Maqbool Hussain, Muhammad Amjad Choudhary, Saleem Abbasi.
Comparison of Injectable Ciprofloxacin and Injectable Ceftriaxone for the Treatment of Hospitalized Patients with Enteric Fever.
Ann Pak Inst Med Sci Jan ;10(4):182-6.

Objective: To determine the efficacy of injectable fluoroquinolone and injectable ceftriaxone in patients with enteric fever. Study Design: Randomized controlled trial. Place and Duration: The study was conducted at District Headquarter Hospital (DHQ), Mirpur, Azad Jammu and Kashmir (AJK) from June 2010 and May 2011. Methodology: All admitted patients with enteric fever were selected in this study at District Headquarter Hospital (DHQ), Mirpur, Azad Jammu and Kashmir (AJK) between June 2010 and May 2011. Injection fluoroquinolone and injection ceftriaxone were randomly given and response was assessed after 5 days. Patients with improvement were continued with the specific drug. However, patients showing no response were changed to chloramphenicol for 10 days. Treatment success was defined as complete recovery from fever after 5 days of treatment. Partial discontinuation of fever and overall symptoms and signs of patient improved after 5 days treatment were labeled as partial recovery and treatment failure as no effect of antibiotic after 5 days of therapy. Results: The average age of patients in group I (inj. Fluoroquinolone) was 34.5 + 17.0 and in group II (inj. Ceftriaxone) 30.6 + 14.7 years. In both groups male gender was in dominance (66% and 73%). In both groups all cases (100%) had positive typhidot results. Injection ceftriaxone was significantly highly successful in the management of enteric fever than injection fluoroquinolone. In injection fluoroquinolone group, 54% cases were resolved compared to 76% with injection ceftriaxone (p-value = 0.002). In group I, 23% failed and required therapy change compared to 10% in group II, these patients were given injectable chloramphenicol and were subsequently resolved. Conclusion: It is concluded that inj. ceftriaxone may be used as first line treatment choice for enteric fever in our local setting.

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