Aurooj Fatima, Robina Kausar, Aisha Yousaf.
Short Term Tocolytic Efficacy of Tarnsdermal Glyceryl Trinitrate (GTN) in Preterm Labour.
Ann Pak Inst Med Sci Jan ;10(4):172-6.

Objectives: To evaluate the tocolytic efficacy of transdermal GTN in preterm labour between 28 to 34 weeks of gestation. Study Design: Descriptive case series. Place and Duration of the Study: It was a conducted at Department of Obstetrics and Gynaecology, Unit-II, Sir Ganga Ram Hospital, Lahore, over a period of six months from 31-07-2010 to 30-01-2011. Materials and Methods: A total of 150 cases included in this study. Total of 150 Pregnant women presenting with preterm labour between 24 and 35 weeks of gestation from early dating scan, age between 15 to 30 years having singleton pregnancy on ultrasonography with any parity and cervical dilatation <4cm on vaginal examination were included in this study. Results: To all 150 patients with preterm labour included in the study, a GTN 10mg/24 hr nitroderm transdermal patch was placed on anterior abdominal wall and replaced by second patch of same dose after 24 hours. Mean age of the patients was 24.9±4.8 years. As for as gestational age is concerned, 16 (10.7%) patients had 24-30 weeks of gestation and 134 (89.3%) had 31-35 weeks gestation. Mean gestational age was found to be 31.9±4.8 weeks. Out of 130 patients, Primigravida were 44 (29.3%). 79 (52.7%) were having parity G2-G4 and 27 (18.0%) patients had parity >G4. Most remarkable results shown by our study was that Glyceryl trinitrate (GTN) efficacy proved in 98 (65.3%) patients. Conclusion: It was concluded from the study that glyceryl trinitrate is a safer tocolytic, which has simple method of application; rapid onset of action, low risk from side effects and it does not require intensive monitoring.

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