Majid Yousefi Moghaddam, Muhammad Naeem.
Outcome of Surgical Clearance of Renal and Ureteric Calculi on Improvement in Renal Parameters in Patients with Renal Insufficiency.
Ann Pak Inst Med Sci Jan ;11(1):47-50.

Objective: To compare the urea and creatinine before, two weeks and four weeks after definitive surgical clearance of renal and/or ureteric calculi in patients with concurrent renal insufficiency . Study Design: An interventional quasi-experimental study. Place and Duration: The study conducted over twelve months from 1st July 2013 at Pakistan Institute of Medical Sciences. Islamabad Materials and Methods: Fifty patients with renal or urteteric calculi with concurrent renal insufficiency (cr>2) were included in the study. Results: After stone clearance surgery creatinine and urea have decrease significantly in 46 (92%) patient’s. However four (8%) patients did not improve on renal parameters and ultimately they needed hemodialysis regularly or renal transplant and surgery did not help them for renal parameters improvement .In this study totally the mean pre-operative serum creatinine was 5.52 ± 2.7 mg/dl and it reduced to 2.03 ± 1.19 mg/dl. The mean reduction in serum creatinine was 4.06 ± 3.05 mg/dl. The mean pre-operative serum urea was 85.4 ± 51 mg/dl and it reduced to 28.4 ± 10.38 mg/dl. The mean reduction in serum urea was 57 ± 40.62 mg/dl. Conclusion: Stone removal can improve renal function after four weeks by eradicating obstruction and, in certain cases, an underlying infection.

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