Abdul Hanan, Muhammad Tahir, Shafique M.
A Study of Response of Ceftriaxone in the Treatment of Tyhphoid Fever.
Ann Pak Inst Med Sci Jan ;11(1):7-11.

OBJECTIVE: To assess the response of IV Ceftriaxone in patients presented with fever and clinically suspected Typhoid fever. METHODOLGY: This cross sectional case series study was conducted in Female Medical Ward of Fauji Foundation Hospital (FFH) Peshawar from January to December 2011. A total of 57 female patients, admitted in medical ward with chief complaint of fever were included in this study. Non probability consecutive sampling technique was used to select the sample. IV Ceftriaxone was given in adult dosage of 2gm once a day (OD) for a period of 7 days to all patients. Data was analyzed in SPSS version 16 for statistics. RESULTS: Total of 57 patients having fever were included in this study. Mean age of patients was 31.19 (+18.305 SD). Typhi Dot was done for all the samples. Negative result was shown by 29 (50.9%) of the total patients. Fever record was maintained for 7 days and their outcome was: On Day 1, all were febrile, on Day 3, 45 (78.9%) were febrile and rest having other symptoms, on Day 5, 9 (15.8%) were recorded to be febrile and rest having other symptoms predominately complaining of lethargy. Temperature was completely resolved by day 7 in all patients. Mean time to defervescence with 2gm IV ceftriaxone OD came out to be 3.89 days with σ of 1.22 days and range being 2 to 6 days. CONCLUSION: This study is unique of its own as it adds to the epidemiological data of typhoid fever in Khyber Pakhtunkhwa where only little data regarding clinical profile of typhoid fever is available. Although patients in our study were treated with a suspicion of typhoid fever after ruling out other causes of febrile illness, the results were comparable to other retrospective studies on typhoid fever conducted on a larger scale.

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