Agha Taj Mohammed, Rasool Bux Behan, Adnan Ahmed.
C-Reactive Protein in Patients with Diagnoses of Cholecystitis.
Ann Pak Inst Med Sci Jan ;12(4):258-61.

Objective: The objective of this study was to find out the association of c reactive protein in patients with cholecystitis. Study Design and Setting: This case-control observational study has been carried out in general surgery department of LUMHS. Duration: Duration was 8 months from December 2015 to May 2016. Methodology: Complete clinical examination and was carried out ultrasound was carried out in all the cases by senior sinologist to conform the cholecystitis. Patients with other associated comorbidities which are associated with C-reactive protein elevation were excluded. Blood sample was taken and send to the diagnostic laboratory to assess the creative protein level. All the data was gathered on self-designed proforma regarding age, gender, clinical features, c reactive protein etc. Results: Total 120 cases have been selected and divided into two groups as: group A 60 with cholecystitis and group B 60 normal cases. Mean age of group A was 40.32+5.3 years and mean age of group B was 38.12+4.5 years. 45(75%) patients were females. Elevated CRP level was found significantly associated with patients having cholecystitis as compare to normal cases P-value 0.001, in group A 45(75%) patients had raised c reactive protein out of 60, while in normal cases elevated CRP level was found only in 2 cases out of 60. 55(91.66%) patients had right upper quadrant pain, 18(30%) had positive murphys sign, 16(26.33%) had fever while 14(23.33%) had elevated WBC count. Conclusion: It is concluded that elevated level of serum CRP is significantly associated with cholecystitis patients as compare to normal cases; therefore, elevation of CRP is the good diagnostic tool for acute cholecystitis.

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