Fazal Karam, Sameeh J Khan, Ghias-ud din Butt.
Lipids Abnormalities in Renal Transplant Recipients.
Ann Pak Inst Med Sci Jan ;9(4):184-7.

Objective: To determine the frequency of dyslipidemia, its types and associated risk factors in renal transplant recipients (RTRs). Study Design: Comparative observational study. Place and duration: This study was carried out in the Department Nephrology, Pakistan Institute of Medical Sciences (PIMS), Islamabad over a period five years. Materials and Methods: This study included all RTRs who were three months posttransplant. Convenience sampling method was employed. The lipid profiles were collected in the outdoor and analysed in laboratory at hospital. An equal number of 54 healthy subjects were randomly collected in the general population at the Out-patient Department of PIMS, Islamabad and their serum lipid profiles were studied as control group for the study. The two groups were matched for age and gender. The data were subjected to statistical analysis. Results: There were 54 stable living RTRs, out of these, 45 were males and 09 were females. The mean age was 34.5+ 9.02 years. The mean duration of transplant was 36.70 ± 38.07 months. The antihypertensive agents used included beta blockers (n=8), calcium channel blockers (n=24), beta blocker and calcium channel blockers in combination (n=12), and the remainder had no antihypertensive therapy (n=10). Immunosuppressive agents instituted were prednisolone (in all patients), Tacrolimus+ Mycophenolate mofetil (n=1), cyclosporine+Azathioprin (n=23), cyclosporine+ Mycophenolate mofetil (n=7), cyclosporine (n=21), and Azathioprin (n=2). The mean levels of total cholestrol (TC), total triglycerides (TG) and high density lipoprotein cholestrol (HDL-C) were increased in transplant group as compared to the controls. There was an inverse relationship between lipid abnormalities and duration of transplant among the RTRs. Conclusion: Dyslipidemia in our RTRs were observed as elevated levels of TC, TG and HDL-C. An inverse relationship between lipid abnormalities and duration of transplant was also noted with hyperlipidemia peaking within the first year after transplantation ( duo to high dose of steroids and immunosuppressive agents used) followed by a reduction thereafter (due to lowering the dose of these medications).

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