Faiqa Saleem, Munazza Malik, Muhammad Shahid, Muhammad Tayyab.
Bacterial vaginosis; comparison between metronidazole vaginal gel and clindamycin vaginal cream for treatment of bacterial vaginosis.
Professional Med J Jan ;24(2):252-7.

In women of reproductive age bacterial vaginosis is a most common polymicrobial disease and is the leading reason for vaginal discharge in this age group. Additionally it is further linked with sizeable disease burden of community problem in terms of infectious complications. Clindamycin vaginal cream and metronidazole vaginal gel are effective in the management of vaginal infections caused by multi bacteria. Objectives: To compare the therapeutic efficacy of Metronidazole vaginal gel and clindamycin vaginal cream as modality of treatment for bacterial vaginosis. Study Design: Randomized control trial. Setting: Department of Obstetrics and Gynaecology, Unit-3 Jinnah Hospital Lahore. Period: Six months from 02-05- 2011 to 01-11-2011. Material & Methods: A total of 300 patients were included in this study. They were divided into two groups. Group A received metronidazole vaginal gel (5 g daily for 7 days) while group B administered with clindamycin vaginal cream (5g daily for 7 days). Results: Mean age of the patient was observed 34.3+3.5 and 32.9+ 2.1 years in group –A and B respectively. Vaginal discharge was absent in 104 patients (69.3%) from group A and 127 (84.7%) from group-B. Absence of clue cells on microscopy revealed in 112 patients (74.7%) from group A and 137 patients (91.3%) from group B. Absence of amine odour found in 116 patients (77.3%) of group A and 134 patients (89.3%) of group B. Significant difference was found between two groups with p value of 0.006 in respect of efficacy. Conclusion: Clindamycin vaginal cream is more effective in comparison to Metronidazole vaginal gel for the treatment of bacterial vaginosis.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com