Muhammad Adnan, Tayyaba Rahat, Naheed Hashmat, Zahra Ali.
Metabolic syndrome; agreement between metabolic syndrome diagnostic criteria among type 2 diabetes mellitus patients.
Professional Med J Jan ;24(4):539-44.

Background: Metabolic syndrome and diabetes mellitus are the modifiable risk factors of cardiovascular diseases that double the chance of illness when occur together. Little work has been reported on the superlative criteria to diagnose metabolic syndrome among diabetics from the country. Therefore, the study was aimed to find the agreement between metabolic syndrome diagnostic criteria among type 2 diabetics. Methods: The retrospective data of 373 known type 2 diabetics who had reported history of taking antidiabetic medicines was analyzed. The new International Diabetes Federation definition, the World Health Organization criteria and the NCEP Adult Treatment Panel III criteria were used to diagnose metabolic syndrome. Data was analyzed by using Statistical Package for Social Sciences version 21. Results: Mean age of 373 diabetics was 49±10 years. Participants included 36.5% males and 63.5% females. Mean BMI, WC and BP were high in females; while HDL-C was low in males (p <0.05). The frequency of MS by ATP III, IDF and WHO criteria were 88.2%; 87.4%; and 86.3%, respectively. Significant association was present between femininity, higher socioeconomic status and MS (p <0.05). ATP III criteria diagnosed the maximum number of MS followed by IDF and WHO criteria. The highest agreement was found between ATP III and IDF criteria (k 0.487). More than 85.0% diabetics were diagnosed as true positive and true negative on all three criteria. The disagreement between the studied criteria ranged from 5.1% to 8.0%. Conclusion: The ATP III, IDF and WHO criteria can equally be used to diagnose metabolic syndrome among type 2 diabetics in the settings. However, ATP III and IDF criteria have an edge over WHO criteria. Increased rate of metabolic syndrome among diabetics have need of serious attention to reduce the risk of cardiovascular events.

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