Haris Alvi, Aslam Arian.
To See the Synergistic Effect of PPI and Itopride in Functional Dyspepsia.
Med Forum Jan ;2(10):2-5.

Objective: To see the synergistic effect of PPI and Itopride in functional dyspepsia Study Design: Prospective descriptive study. Place and Duration of Study: The study was conducted in a tertiary care hospital, Al-Tibri Medical College & Hospital, a three hundred bedded hospital from Feb 2011 to Dec 2011. Materials and Methods: The patients reported in the OPD were included in this study and they were screened according to inclusion criteria with complained of upper abdominal pain, fullness, chest burning and bloating. All the data were recorded in a preset performa and result were analyzed by SPSS version 15. Results: A total of 54 cases were included. Male were 25 and females were 29. All the patients were presented to OPD with upper abdominal pain 51 cases, chest burn 49 cases, abdominal fullness43 cases and bloating in 37 cases. The symptoms were persistent for more than two weeks. The entire patients were inquired about the comorbids, like hypertension, diabetes mellitus, ischemic heart disease, rheumatism, or on steroids and that all excluded from the study. All the patients had negative H Pylori status and had undergone upper gastrointestinal endoscopies. All the patients were started on PPI and itopride in low and high dose regime according to the symptoms. Improvement of the symptoms was accessed at the end of fifth day. Nearly 82 % of the patients had improved on the fifth day of the therapy while the other the rest of the patients were started with a higher dose and additional 10 % were benefited at the end of 2nd week. All the patients were treated for four week and then they were followed for next four week for the recurrence of the symptoms. In the first follow-up of four weeks 44% of the patients had sustained complete response in their symptoms. Conclusion: The combination of PPI and Itopride has synergistic effect in functional dyspepsia. Further studies are required to prove their efficacy.

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