Iffat Ara, Munir Ahmad Khan, Naseem Akhtar, Tahira Majeeda Malik, Nasreen Javed, Talat Ahmed.
Effect of Cyproheptadine alone and in combination with Aspirin on Platelet Aggregation.
Pak Armed Forces Med J Jan ;50(1):20-5.

The antiplatelet effect of cyproheptadine was studied on platelet rich plasma (PRP) of 30 adult healthy human volunteers. It was compared with aspirin. Moreover, the combined effect of two drugs was also studied. The platelet aggregation (PA) was induced with adenosine diphosphate (ADP) and combination of 5-hydroxytryptamine (5-HT), and epinephrine. Cyproheptadine is found to be an inhibitor of PA. It is significantly more potent inhibitor of PA than that of aspirin (p < 0.001) in 5-HT plus epinephrine induced PA. It also has a synergistic effect with aspirin. Prophylactic therapy with combination of aspirin and cyproheptadine may be more beneficial in patients of occlusive vascular disease.

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