Abdul Qavi, Ghulam Nabi Khokhar, Amjad Zahoor, Israr Ahmed Akhund, Muhammad Ishaq.
Significance of Hypercholesterolemia in Hypothyroid Patients.
Med Forum Jan ;2(12):86-8.

Introduction: Lipid and lipoprotein is influenced by thyroid hormone. Global distribution thyroid disease is very common in Indo- Pak. Hypercholesterolemia is common finding in hypothyroid patients. Objective: This study was conducted to know the prevalence of thyroid dysfunction and its relationship with dyslipidemia. Study Design: Cross Sectional Study Place & Duration of Study: This study was conducted at the Department of Pathology Jinnah Medical College Warsak Road Peshawar for the period from December 2012 to May 2013. Materials and Methods: 300 patients suspicious of thyroid element were included in study group. 100 healthy control subjects with no history of any thyroid and other chronic illness were included in control group, serum FT4, TSH and total cholesterol was estimated by Elisa and colorimetric method respectively and Results were analyzed by applying “student T test” and “Chi- square”. Result: Out of 300 sera tested 78 (260) had thyroid dysfunction Hypothyroid patients serum showed significantly raised cholesterol level, however no significant association between total cholesterol and raised thyroxin level observed. Conclusion: Hypercholesterolemia was noted significantly in hypothyroid patients indicating need for monitoring the cholesterol level in thyroid dysfunction to avoid the risk of development of cardiovascular disease.

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