Talha Bin Fayyaz, Zahida Memon, Mirza Tasawer Baig, Noor-ul Ain, Muhammad Saddam Aziz.
Hematologic Toxicosis; Induced By Doxorubicin Protective Effects Of Combination Of Olea Europeae And Ginkgo Biloba.
Professional Med J Jan ;24(5):751-6.

Objectives: To evaluate the protective effects of combination of extracts of Olea europeae and Ginkgo biloba in response to hematological toxicosis induced by DOX. Design of study: Animal experimental study. Setting: Dow University of Health Sciences. Period: 2 month. Materials & methods: The extracts of Olea europeae and Ginkgo biloba were prepared by using standard Soxhlet apparatus and then they were mixed together in 1:1 ratio. Eighteen Male Wistar rats were incorporated in the study and divided in 3 groups: T* (control group: 2 ml 0.9 % NS), TP0 (DOX group: 15 mg/kg/week) and TP1 (extract of Olea europeae & Ginkgo biloba + DOX: 200 + 15 mg/kg/week). All animals receive drugs by intra-peritoneal route. On 57th day blood was withdrawn by cardiac puncture and preserved for analysis. Hematological profile includes CBC and Platelet count. Results: Hematological analysis reveals that the animals which receive Doxorubicin had low levels of Hemoglobin, RBCs, Leukocytes, Neutrophils, Eosinophils, Monocytes, Lymphocytes and Platelets when compared to control group. The levels of Hb and RBCs were low but it is not evident of anemia. Neutrophil and Platelet were drastically low, which shows presence of Neutropenia and Thrombocytopenia. The treated group animals had shown positive elevation in the levels of CBC and Platelet count. Conclusions: On the basis of hematological report it is concluded that combination of extracts of Olea europeae and Ginkgo biloba can prevent the toxicosis effects of Doxorubicin.

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