Nahdia Ashraf, Muhammad Usman Hussain, Iqra Qamar, Muhammad Ashraf.
Anti HBS Titre; Among Outgoing Final Year MBBS Students.
Professional Med J Jan ;24(8):1167-9.

Introduction: The doctors and paramedical staff are at high risk of developing Hepatitis B, infection. Hepatitis B vaccine is mandatory for medical students prior to admission in medical colleges. After completion of vaccination determination of anti HBS is not in practice. All over the world some people remain non responders and don’t develop adequate antibody titre essential for protection against hepatitis B virus. This study is therefore designed to estimate the anti HBs titre among the medical students, who have completed three doses of hepatitis B vaccine. Objectives: To determine the serum anti HBs antibodies among the outgoing final year MBBS students who have received complete 03 doses of hepatitis B vaccine. Study Design: Descriptive cross sectional study. Place and Duration: This study was conducted from November 2010 to December 2015 at Biochemistry department Punjab Medical College in collaboration with Nawaz Medicare Hospital Faisalabad. Material and Methods: Two hundred and fifty nine female medical (MBBS) students from outgoing classes during the period of November 2010 to December 2015 were enrolled in this study. All subjects were at the age of 22-24 years at the time of sampling. Each received 03 doses of injection Engerix B, 10 mcg/0.5ml each in a schedule of 0, 01, 06 months since the last 05 years. The blood samples were allowed to clot and serum was separated. The anti HBs and HBsAg were determined by 3rd generation ELISA method. Results: A total 259 female medical students from outgoing final year MBBS classes were enrolled in this study. Among these subjects 48 (18.5%) had serum anti HBs levels < 10 IU/L, 77 subjects (29.7%) have levels 10-20 IU/L, 116 subjects (44.8 %) have serum levels 21-100 IU/L, while 18 subjects (10%) have > 100 IU/L serum anti HBs levels. Conclusion: The incidence of non responders and poor responders is higher among the vaccinees in this study as compared to foreign studies after five years of Hepatitis B vaccination.

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