Nazia Bashir Abbasi, Nighat Jabeen, Shafat Khatoon.
Neonatal Sepsis; Common Bacterial Isolates And Their Antimicrobial Susceptibility Patterns In Neonatal Intensive Care Unit, Islamabad.
Professional Med J Jan ;24(10):1455-60.

Introduction: Neonatal sepsis is a systemic condition characterized by bacteremia that occurs in the first month of life. It is a fatal condition and need to be treated promptly. Bacterial isolates include both gram positive and negative bacteria and the cure of condition is highly dependent on antimicrobial drug sensitivity and resistant patterns. It is there for utmost important to known commonly occurring bacteria in neonatal septic states and their drug sensitivity patterns. Objectives: To determine the frequency of the bacterial isolates in blood and their sensitivity patterns to commonly used antibiotics in neonatal sepsis. Setting: Neonatal intensive care unit(NICU), Department of Shifa International Hospital. (SIH), Islamabad. Study Design: Cross sectional. Duration: This study was conducted between 6 1st June 2013 to 30th November 2013. Subject and Methods: A total of 180 neonates, admitted in NICU with evidence of clinical sepsis i.e. with signs and symptoms suggestive of septicemia (fever, lethargy, reluctance to feed, seizures, and irritability) were included in this study. The samples for blood cultures were taken. Identification of bacterial isolates was carried out by the standard bacteriological techniques, which include gram staining and bacterial cultures and antimicrobial sensitivity patterns which was performed by modified Kirby and Bauer disc diffuse method as per CLSI (Clinical and Laboratory StandardsInstitute)guidelines.A predesigned Performa was filled. Results: Culture revealed bacterial growth in 7.2% samples. Gram negative organisms were observed in 6.67% and only 1 were gram positive. In this study, 50% and 100% of E-coli were sensitive to ampicillin, meropenem and amikacin, gentamycin respectively. Sixty to 100% of pseudomonas was sensitive to ceftazidime, tazobactum, meropenem and 100% of enterococcus was sensitive to ampicillin and vancomycin. Conclusion: Antimicrobial drug resistance and constantly changing resistance patterns is emerging issues in various groups of infections and septic states, especially for routinely used antibiotics as found in our study. Thus by prescribing rational use of antimicrobial as per bactriogram, It‘ll be easier totreat sepsis effectively and economically and reduce the mortality and morbidity related to neonatal sepsis.

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