Abdul Raqeeb, Azhar Memon, Mona Humaira, Haji Khan Khoharo.
ADULT HEALTHY SMOKERS; Lipid peroxidant and antioxidant activity.
Professional Med J Jan ;23(07):770-4.

Objectives: To determine superoxide dismutase (SOD), glutathione peroxidase (GPX), and malondialdehyde (MDA), uric acid and serum bilirubin in healthy adult smokers. Study Design: Case control study. Place and Duration: Liaquat University of Medical and Health Sciences Hospital. Hyderabad, Sindh from December 2013 - July 2014. Subjects and Methods: 77 smokers and 50 healthy controls were selected through non-probability purposive sampling. Blood glucose, lipids, MDA, antioxidant enzymes (SOD & GPX), serum bilirubin and uric acid (UA) were measured. Data was analyzed on Statistic software 8.1 by student’s t test and Chi square test. The significant p-value was taken at ≤ 0.05. Results: Anti-oxidant enzymes (SOD & GPX), blood lipids, lipid per oxidant marker; the MDA, bilirubin and UA showed statistically significant differences between smokers and controls (p<0.001). Total blood lipids and lipid sub fractions were elevated in smokers. MDA in smokers was 3.17±0.91 µmol/ml compared to 1.15±0.61 µmol/ml (p=0.001) in controls. Smokers showed reduced SOD, GPX, serum bilirubin and UA, was significant (p=0.0001) in comparison to controls. Conclusion: Cigarette smoke is a significant source of oxidative stress. Smoking increases malondialdehyde and reduces superoxide dismutase, glutathione peroxidase, uric acid and bilirubin.

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