Faizania Shabbir, Muhammad Alamgir Khan, Tausif Ahmed Rajput.
DUAL EFFECT OF ATORVASTATIN ON ENDOTHELIUM; Reduction in ldl and txa2 levels but unaltered hcy levels in obese hyperlipidemic rats.
Professional Med J Jan ;22(09):1196-202.

The objective of the study was to observe the effect of lipid lowering therapy on homocysteine and TXA2 concentration in obese hyperlipidemic Sprague Dawley rats. Design: Randomized Control Trial (RCT). Place and Duration of study: The study was conducted in Department of Physiology and Centre for Research in Experimental and Applied Medicine (CREAM), Army Medical College, Rawalpindi; and National Institute of Health (NIH) Islamabad over a period of 12 months. Methodology: Ninety healthy Sprague Dawley rats divided into three equal groups. Group I (n=30) were healthy controls, group II (n=30) were made obese and group III (n=30) were obese treated (atorvastatin 10 mg/kg/day orally by gavage method for three weeks). Body weight was recorded thrice weekly, lipid profile was measured by colorimetric method on microlab and homocysteine and TXA2 were measured by Enzyme Linked Immunosorbant Assay. Results: Serum low density lipoproteins and TXA2 decreased after three weeks of atorvastatin administration, elevated HCY concentration in obese hyperlipidemic rats however was not significantly affected. Conclusion: Atorvastatin apart from lowering lipid levels in the body also reduces TXA2 concentration which is a vasoprotective. Elevated HCY concentration which is deleterious to the endothelium however is not affected.

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