Muhammad Khalid Siddiqui, Sikander Adil Mughal, Muhammad Saeed Siddiqui, Atif Sitwat Hayat.
EFFECTS OF L- CARNITINE; Skeletal muscle of rabbit.
Professional Med J Jan ;22(8):1001-6.

L-carnitine (L-car) is a trimethylated amino acid required for the transformation of long chain free fatty acids into acylcarnitine and their subsequent transport into the mitochondrial matrix. It enhances the fatty acid oxidation for energy thus delaying the skeletal muscle fatigue. Objectives: Objectives of this study were to determine effect of L-carnitine supplementation on skeletal muscle lactate after fatigue, to observe effect of L-carnitine supplementation on force of contraction in skeletal muscle and to estimate the time to onset of fatigue after L-carnitine supplementation. Animals & treatment: In control group, the rabbit sedated and soleus muscle was excised, Homogenized and centrifuged. Supernatant collected, was mixed with reagents of lactate test kit. Absorbance of light was read with the help of spectrophotometer and readings were noted. In experimental group, L-carnitine was given in a dose of 80mg / kg. The period of administration was two weeks. Soleus muscle was excised after giving the last dose of L-carnitine.Lactate level was measured by using lactate test kit (Randox®). Readings for lactate measurement were noted after fatigue in both groups. Results: Statistically significant results (p <0.05) were found in all three variables. Data was analyzed by applying “t” test in IBM SPSS Statistics - 20 soft ware. Conclusion: L -carnitine delays the onset of fatigue of skeletal muscle. This was the stated alternative hypothesis.

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