Alwahaibi M S, Ashique M, Ramkumar A, Nemmar A, Andali B H.
Motor And Behavioural Effects Of Ferulic Acid In Mice With Cisplatin-Induced Nephrotoxicity.
Biomedica Jan ;32(4):246-52.

Background and Objective: Cisplatin (CP) is commonly used to treat solid tumors. It is known to cause nephrotoxicity as well as some motor and behavioral impairments. Ferulic acid (FA) is a phenolic compound with antioxidant and anti-inflammatory properties. The present study was designed to assess the protective effects of ferulic acid on cisplatin toxicity in mice. Methods: Four randomly-grouped male albino mice were treated as follows: saline (control), CP (10 mg/kg [i.p. twice]), FA (100 mg/kg, orally, 14 day) and a combination of CP and FA treatments. Motor and behavioural experiments were conducted on mice on the first, eighth and fifteenth day for the evaluation of basal motor activity (activity cage), exploration (hole-board), neuro-muscular coordination (rota rod treadmill, grip strength), nociception (hot plate, cold-water tail flick, acetic acid-induced writhing and depression-like behaviour. Results: CP significantly increased the plasma creatinine and urea concentrations. It also significantly prolonged the time on hot plate test and reduced the acetic acid-induced abdominal constrictions suggesting an antinociceptive action. It significantly decreased the time on rotarod treadmill and grip strength tests, indicating impairment in neuro-muscular coordination. CP also decreased the exploratory action, and induced depression-like behaviour. FA significantly (p<0.05) improved the basal motor activity, neuromuscular coordination, motor activity, exploration activity and the depression-like action in CP-treated group. Conclusion: FA showed an anti-depressant-like action, and improved the motor and exploratory activeties in CP-treated mice.

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