Sarah Shami, Zainab Subhan, Muzammil Jamil Ahmed Rana.
Efficacy of naproxen in management of postoperative endodontic pain in teeth with irrevenrsible pulpitis.
Pak Oral Dental J Jan ;36(3):476-9.

Prevention or management of pain is an important objective in root canal treatment (RCT). Post endodontic pain has always been an important concern for patients and clinicians. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used analgesics for the management of endodontic pain. Naproxen is member of this family, which inhibits the cyclooxygenase pathway and prevents the release of inflammatory mediators. The objective of this study was to compare the mean postoperative endodontic pain using Naproxen and placebo (no drug) in patients with irreversible pulpitis. This study was carried out over a period of six months (01-07-2014 to 31-12-2014) in the Department of Operative Dentistry, Armed Forces Institute of Dentistry (AFID), Rawalpindi. Sixty patients (30 in each group) were scored in this study. Patients in Group-A received tablet Naproxen (500mg) and those in Group-B (placebo) received a starch containing capsule. Mean age of the patients was 34.47±9.51 years in Group-A and 32.43±8.90 years in Group-B. In Group-A 19 patients (63.3%) and in Group-B 14 patients (46.7%) were males. In Group-A 11 patients (36.7%) and in Group-B 16 patients (53.3%) were females. Mean pain score after 24 hours was 0.97±1.06 and 4.93±1.14 in Group-A and B, respectively. The difference between two groups was statistically significant (p<0.001).The study concluded that naproxen is effective in reduction of post-endodontic pain in teeth with irreversible pulpitis.

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