Tooba Lateef, Hafsa Rukash, Faiza Bibi, Uhammad Bilal Azmi, Muhammad Bilal Azmi, Shamim Akhtar Qureshi, Shamim Akhtar Qureshi.
Effect of Convallaria majalis on Kidney Function ,.
J Dow Uni Health Sci Jan ;10(3):94-7.

Objective: To evaluate the effect of Convallaria majalis on kidney function. The kidneys are vital organs that perform a variety of important functions in our body. Primary and secondary causes of kidney diseases produce changes in glom erular filtration rate that m ay leads to kidney failure. Blood parameters such as uric acid and creatinine are used to assess kidney function. C. majalis (CM) com m only called as Lily of the valley is a Homoeopathic remedy having valuable action on heart and also has diuretic action. Methods: In the present study, the effect of CM was investigated on serum uric acid and creatinine, by administrating orally 70% alcoholic extract of CM (10 and 50 m g/kg), simvastatin (20 m g/kg), 0.05% dimethyl-sulphooxide (DMSO, 1ml/kg) and distilled water (1ml/kg) to test (A & B groups), positive, negative and control rabbits respectively for 14 days consecutively once in a day. On completion of trial, rabbits were sacrificed to collect blood and serum was separated to estimate uric acid and creatinin e levels. Results: Out of two tested doses, 10 mg/kg of CM produced significant decrease in uric acid levels from 10.97­ 8.40 mg/dL in test rabbits (Test A) when compared with control, negative & positive control groups (p<0.05). However, the same dose of extract showed no effect on serum creatinine levels. Whereas alcoholic extract @50mg/kg was found in effective in reducing either of serum uric acid and creatinine levels. Conclusion: According to the data, alcoholic extract of CM @ 10mg/kg was found as a significant hypouricemic agent.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com