Nasir Mahmood, Abdul Baseer, Abdul Khaliq Naveed.
Serum and Breast Tissue Glycoproteins in patients with Tumors of Breast.
Pak Armed Forces Med J Jan ;52(1):51-6.

Carcinoma of breast is among the commonest of human cancers throughout the world and different methods of diagnosis and progression of the disease including serum glycoproteins have been studied by various workers. Combined analysis of serum and breast tissue glycoproteins was studied in 70 patients, 20 with benign breast tumours and 50 with malignant breast tumours, (15 patients each of cancer stage I&11, 8 patients of cancer stage III and 12 patients of cancer stage IV) and 20 healthy females with no family history of breast tumour as control subjects. Significantly increased levels of serum fucose in all groups of patients (P<0.001), serum mucoprotein, benign tumour patients (P<0.001), cancer stage I (P<0.001), cancer stage II (P<0.02), cancer stage III (P<0.01) and cancer stage IV (P<0.01), serum sialic acid in cancer stage IV patients (P<0.05), serum protein bound hexoses in benign tumour patients (P<0.02), cancer stage I (P<0.02), cancer stage II (P<0.05), cancer stage IV (P<0.05), serum hexosamine in benign tumour patients (P<0.01), cancer stage I (P<0.01), cancer stage II (P<0.01) and cancer stage IV (P<0.05) were observed in these patients compared to the control subjects. A direct relationship between serum and breast tissue glycoproteins was observed in these patients on correlation coefficient. Therefore combined analysis of serum and breast tissue glycoproteins in these patients gives more information which is helpful in diagnosis and progression of the disease as compared to analysis of only serum glycoproteins.

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