Abrar Hussain Azad, Haroon Rashid Khan, Ghulam Mujtaba Nasir, Muhammad Afzal.
Lipid Profile Abnormalities in Controlled and Uncontrolled Diabetic Patients: A Comparative Study.
Ann Pak Inst Med Sci Jan ;13(2):208-12.

Objective: To compare the lipid profile abnormalities in controlled and uncontrolled diabetic patients on the basis of HbA1c. Study Design: Cross-Sectional Comparative Place and duration of study: This study was carried out at OPD of DHQ Hospital, Mirpur AJK from October 2016 to January 2017. Methodology: Diagnosed patients with type 2 diabetes of both genders and having age from 35 to 65 years were included in the study. A total of 156 diabetic patients were included in the study consisting of two equal groups of 78 patients in controlled diabetes group and 78 in uncontrolled diabetes group. The patients were divided into controlled (≤ 7%) and uncontrolled (> 7%) groups on the basis of HbA1c, which was calculated from venous blood samples collected after at least 8 hours fasting. The laboratory tests including fasting plasma glucose, HbA1c level and lipid profile (Serum TC, HDL-C, LDL-C and TG) were measured. Results: The mean value of age in controlled and uncontrolled DM group was 52.91 ± 7.89 and 53.89 ± 8.37 years. There were 75 (48.08%) male and 81 (51.92%) female patients in the total study sample. The ratio of female patients (62.82% vs. 37.18%) was significantly higher in controlled diabetes mellitus group. In controlled DM group (37.18%) of patients were practicing exercise as compared to (16.67%) patients of the uncontrolled group. In uncontrolled DM group, 49 (62.82%) and 32 (41.03%) in controlled DM group had a positive family history of DM. The serum total cholesterol level was found significantly raised in patients with uncontrolled DM (pvalue = 0.003). The level of serum triglycerides was significantly (p-value = 0.036) high in patients of uncontrolled DM group. The level of serum HDL cholesterol was recorded to have the reverse pattern and it was observed that HDL cholesterol level was significantly (p-value = 0.013) lower in uncontrolled DM patients. Serum LDL cholesterol level was found significantly (p-value = 0.042) raised in uncontrolled DM patients. Conclusion: The glycemic control of the patient has got a strong impact on the serum lipid level and dyslipidemia is frequently encountered in those who have got poor glycemic control.

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