Ghulam Mujtaba Nasir, Haroon Rashid Khan, Abrar Hussain Azad, Muhammad Afzal.
Association of Glycemic Control and Chronic Hepatitis C Virus Infection in Patients of Type 2 Diabetes Mellitus.
Ann Pak Inst Med Sci Jan ;13(2):181-5.

Objectives: To determine the association of glycemic control with HCV infection among the patients of type 2 diabetes mellitus. Study Design: Descriptive Cross Sectional Duration and Setting: This study was conducted from June 2016 to January 2017 in OPD’s of General Medicine, Pakistan Institute of Medical Sciences Islamabad, and Mohtarma Benazir Bhutto Medical College Mirpur. Methodology: This cross-sectional study was started after taking approval form hospital ethical committee. In this study a total of 108 patients of type 2 diabetes mellitus were included. Type 2 Diabetic patients fulfilling the inclusion and exclusion criteria were selected for the study and were advised anti HCV antibodies by 3rd generation ELISA. The samples were sent for anti HCV antibodies, blood sugar and HbA1c. The type 2 diabetic patients were considered of having good glycemic control with the help of HbA1c ≤ 6.5 % and patient with > 6.5 % HbA1c value were considered as having poor glycemic control. Results: The mean age of the patients was 43.5 years with standard deviation of 6.8 years. There were 49 (45.37%) male and 59 (54.63%) female patients in the study. The HCV infection was present in 15 (13.89%) patients of type 2 diabetes A large number of patients 77 (71.29%) had poor glycemic control on the basis of HbA1c level and only 31 (28.70%) patients had good glycemic control. The rate of HCV infections was considerably higher 33.77% in poor glycemic control patients as compared with the 22.58% patients whose glycemic control was good, but the result was not statistically significant having p-value of 0.2536. Conclusion: The frequency of HCV infection among type 2 diabetic patients having poor glycemic control is substantially high as compared to patients of good glycemic control group.

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