Ahmed Waqas, Shahzad Ahmed Qasmi, Muhammad Amir Mian, Ahmed Raza, Rana Hassan, Ameer Yasir Zaid.
Ondansetron Versus Combined Dexamethasone and Metoclopramide In Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy.
J Surg Pak Jan ;18(2):59-63.

Objective: To compare the efficacy of combined metoclopramide and dexamethasone with ondansetron in preventing nausea and vomiting after laparoscopic cholecystectomy. Study design: Randomized controlled trial. Place & Duration of study: Surgical Unit I Combined Military Hospital Rawalpindi, from 1st June 2010 to 3rd January 2011. Methodology: A total of 120 patients were observed for 24 hours after elective laparoscopic cholecystectomy for nausea and vomiting and divided into two groups of 60 patients each. Nausea and vomiting was rated by the patients according to a three point scale (0=no nausea and vomiting, 1= nausea, 2= retching or vomiting). Results: Early postoperative nausea and vomiting was not present in 31 (51.7%) patients of group I and 40 (66.7%) of group II (score = 0). In 11 (18.3%) patients of group I and 12 (20.0%) of group II only nausea was present (score = 1), while 18 (30.0%) patients in group I and 8 (13.3%) in group II scored 2. The late postoperative nausea and vomiting was not present in 21 (35.0%) patients in group I and 37 (61.7%) in group II (score = 0). In 28 (46.7%) patients in group I and 22 (36.7%) in group II nausea was present (score = 1) while 11 (18.3%) patients of group I and 1 (1.7%) in group II scored 2. Conclusion: Ondansetron was effective as compared to combined metoclopramide and dexamethasone in prevention of post-laparoscopic cholecystectomy nausea and vomiting.

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