Rana Hussain, Sarwat Jehan, Musharraf Jehan.
Obesity and Insulin Resistance Among Infertile Women With Polycystic Ovarian Syndrome.
J Surg Pak Jan ;18(4):175-8.

Objective: To find out the frequency of obesity and insulin resistance among infertile women with polycystic ovarian syndrome (PCOS). Study design: Descriptive case series. Place & Duration of study: Baqai Institute of Reproduction & Developmental Sciences (BIRDS), from July 2012 to June 2013. Methodology: Women who had PCOS were selected on the basis of Rotterdam criteria between the ages of 16 to 40 years. Detailed history, physical examination, transvaginal ultrasound and hormone profile were done. Women who had other endocrinological problems like thyroid disorder, hyperprolactinemia, diabetes mellitus, Cushing syndrome and androgens producing tumours were excluded from the study. Results: A total of 318 (35.49%) infertile women were diagnosed as PCOS out of 896 women who visited BIRDS during the study period. Majority (n=178 - 55.97%) of the women were between 21-30 years of age. Oligomenorrhea was the commonest menstrual irregularity found in 203 (63.83%) women. Mild hirsutism was noted in 204 (64.15%) women. On transvaginal scan PCO were observed in 298 (93.71%) women. Class I obesity was observed in 64 (20.12%), while 8.49% (n=27) had class II obesity. Class III obesity was found in 2(0.62%) women only. The number of overweight women was 132(41.50%). High LH/FSH ratio was found in 185 (58.17%) women. Insulin resistance was observed in 201(63.20%) women. Conclusion: All manifestations of PCOS were more frequent and severe in obese patients.

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