Humaira Tahseen, Kaniz Zehra Naqvi.
Single Dose Prophylactic Antibiotic Versus Routine 5 Days Prophylactic Antibiotic in Prevention of Postoperative Infection in Elective, Clean Abdominal Gynecologic Surgeries.
J Surg Pak Jan ;19(3):87-91.

Objective: To compare the efficacy of single dose versus routine five days prophylactic antibiotic in prevention of postoperative infection in elective gynecologic and obstetric surgeries. Study design: Randomized control trial. Place & Duration of study: Department of Obstetrics and Gynaecology Liaquat National Hospital & Medical College Karachi, from August 2010 to August 2011. Methodology: A total of 303 patients undergoing elective gynecologic and obstetric surgeries were included. Patients were randomly divided into two groups with 153 patients each. One group received single dose of antibiotic at the time of induction of anaesthesia and other received 1st dose at induction of anesthesia, 2nd after 12 hours and then two doses daily 12 hourly for 5 days. Rate of postoperative infections in terms of wound infection, urinary tract infection and febrile morbidity, were recorded. Results: The commonest surgical procedure performed were cesarean section in both the groups followed by total abdominal hysterectomy. There was no statistically significant difference in the rates of postoperative wound infection on 2nd (0% vs 2.6%, p = 0.123) and 21st (0.7% vs 0.7%, p = 0.99) postoperative day in both the groups. Similarly febrile morbidity on 2nd postoperative day was (3.3% vs 4.6%, p=0.56) and no fever observed on 21st day of surgery in both the groups. As regards the urinary tract infection there was no statistically significant difference between the groups on 2nd day (22.9% vs 14.4%, ??? p= ) and 21st day (5.2% vs 2.6%, p = 0.24). Conclusions: Both the regimens were equally effective against postoperative infectious morbidity. Single dose of prophylactic antibiotic prevented unnecessary long course of antibiotic and potential antibiotic resistance.

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