Ubaid-ur Rehaman, Sadaf Durrani, Ubaidullah, Sabia Ali, Muddassir Ahmad Khan, Saif-ur Rahman Wazir.
The Testosterone Status In Overweight Young Adults Of Peshawar.
J Med Sci May ;25(1):80-3.

Objective: To see whether obesity decreases the testosterone concentration in young male adults, who have no other cause of decreased testosterone. Material & Methods: This was a comparative, case control and cross sectional study conducted in the Department of Biochemistry, Khyber Medical College, Peshawar - Pakistan. The study period was from January 2016 to December 2016, consisting of two groups, A and B, each having 32 subjects. Group A had BMI of >25 Kg/m2 while the control group B had BMI of < 25 Kg/m2. Their testosterone concentrations were compared keeping other confounding factors like age, sex, educational status and socioeconomic conditions constant. The weight in Kg and height in meters were measured for each subject and then BMI was calculated. A blood sample of approximately 5-ml was collected from each participant. The sera were prepared and stored in labeled tubes which were then properly sealed, placed in racks and were stored in a freezer at -20oC till further analysis. The samples were analyzed for serum Testosterone level by Radioimmunoassay (RIA) method. Results: Group A had 32 obese subjects having a BMI 26.9 Kg/m2 with a SD of 1.501. The testosterone concentration of group A is compared with that of control group B having a normal BMI of 21.7 with a SD of 1.557. Testosterone concentrations of the two study groups revealed a significant difference (P< 0.001) when compared by the independent sample t-test. Conclusion: The increase trend of obesity in elderly people and now in young adults should be prevented as it lower serum testosterone concentrations, apart from other hazards like diabetes, hypertension, CVD and osteoarthritis.

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