Saima Mustafa, Sadia Fatima, Tafheem Khosa, Furhan Iqbal, Hira Fatima, Rehan Sadiq Shaikh, Atif Akbar.
Association of single nucleotide polymorphism in CD28(C/T-I3 + 17) and CD40 (C/T-1) genes with the Graves\' disease.
J Pak Med Assoc Jan ;68(1):3-9.

Objective: To find out a correlation between the single nucleotide polymorphisms in cluster of differentiation 28 and cluster of differentiation 40 genes with Graves' disease, if any. Methods: This case-control study was conducted at the Multan Institute of Nuclear Medicine and Radiotherapy, Multan, Pakistan, and comprised blood samples of Graves' disease patients and controls. Various risk factors were also correlated either with the genotype at each single-nucleotide polymorphism or with various combinations of genotypes studied during present investigation. Results: Of the 160 samples, there were 80(50%) each from patients and controls. Risk factor analysis revealed that gender (p=0.008), marital status (p<0.001), education (p<0.001), smoking (p<0.001), tri-iodothyronine (P <0.001), thyroxin (p<0.001) and thyroid-stimulating hormone (p<0.000) levels in blood were associated with Graves' disease. Conclusion: Both single-nucleotide polymorphisms in both genes were not associated with Graves' disease, either individually or in any combined form.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com