Aliena Badshah, Mohammad Humayun.
Anti-Mitochondrial Antibody Negative Primary Biliary Cirrhosis: A Case Report.
J Postgrad Med Inst Jan ;30(4):376-8.

Primary Biliary Cirrhosis (PBC) is an idiopathic, cholestatic destruction of intra-hepatic microscopic bile ducts. Up to 80% of the patients presenting with PBC are females. Patients usually present with fatigue, pruritis and jaundice. Suspicion of PBC arises when cholestasis and cirrhosis are present in middle-aged women. Anti-mitochondrial antibodies (AMA) are present in 95% of the patients. AMA is considered the serological hallmark of PBC, but may be absent in a proportion of these patients. We hereby present a case of AMA-negative PBC.

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