Sahibzada Mahmood Noor, Mohammad Majid Paracha, Hina Ali Khan.
Causative Factors And Clinical Outcome In Steven Johnson Syndrome And Toxic Epidermal Necrolysis.
J Postgrad Med Inst Jan ;31(2):184-7.

Objective: To identify the main factors causing Steven Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) and their clinical outcome in the patients in our local setup. Methodology: This case series was conducted at Lady Reading Hospital, Peshawar. A total of 54 consecutive patients who presented with Steven Johnson syndrome and toxic epidermal necrolysis over a two year period (2013-2015) were included in the study. Relevant information including bio-data, causative agents, duration of hospital stay and outcome in terms of improvement or mortality was collected. Analysis was done using SPSS version 20. Results: The mean age of patients presenting with SJS/TEN was 25.9±17.4 years with a minimum age of 1 year and a maximum age of 65 years. Majority of patients were between 18-45 years of age. The causes identified for triggering SJS/TEN were anticonvulsants (38.9%), followed in equal frequency by antibiotics and NSAIDS (27.8%) while 5.5% of cases were secondary to herpes virus infection. Patients had a variable course with 83.3% of patients improving with no sequel on follow-up and 16.7% succumbing to the disease. Conclusion: Anticonvulsants, antibiotics and NSAIDS were the most frequently responsible drugs for development of SJS & TEN. The Observed mortality rate was 16.7%.

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