Saira Dars, Naheed Akhter, Safia Malik.
Management Of First Trimester Miscarriage By 800-uG Vaginal Misoprostol Compared With Expectant Management.
J Postgrad Med Inst Jan ;31(2):110-3.

Objective: To compare the safety and effectiveness of expectant management with medical management by misoprostol in cases of first trimester miscarriage. Methodology: This case-control study was conducted in the Department of Obstetrics and Gynecology, Liaquat University Hospital, Hyderabad (Sindh) Pakistan, from December 2010 to November 2012 (two years). From 124 women, 62 were managed by up to two doses of 800-µg misoprostol intra-vaginally and 62 expectantly. If products of conception were not completely expelled till 7th day then manual vacuum aspiration or dilatation and curettage was performed. Reports of complications were sought up to 8 weeks. Results: There was 83.87% success rate in misoprostol group and 48.39% in expectant management group (P<0.001). No statistically significant difference in side-effects or complications was observed. Patient satisfaction rate was significantly higher in misoprostol group (P<0.01). Conclusion: Vaginal misoprostol is almost as safe as expectant management as well as significantly more efficient and satisfactory for the management of first trimester miscarriages.

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