Robina Usman, Farzana Khan, Munaza Khattak, Zain-ul Abideen.
Correlation Of Vitamin D With Hypertension In Patients With Cardiometabolic Syndrome.
J Postgrad Med Inst Jan ;31(3):299-303.

Objective: To find out correlation between vitamin D and hypertension in patients with cardiometabolic syndrome (CMS). Methodology: It was a case control study carried out from January to April 2012. Fifty adult patients of CMS and fifty controls were selected in Endocrinology Unit of Hayatabad Medical complex (HMC) by purposive sampling. Controls were age and gender matched relatives of patients. CMS patients were selected by IDF criteria. Waist circumference and blood pressure was recorded. Fasting blood sugar and lipid profile were assessed. 25-hydroxy vitamin D concentrations in serum were estimated by ELISA in HMC pathology laboratory. Analysis was done by using SPSS 17. Chi-square test was applied among individuals with different blood pressure and vitamin D2 levels. Results: Mean systolic BP was 141.82 ±15.16 and 119.84 ±7.20 mmHg in patients and controls respectively, whereas mean diastolic BP was 88.70 ±6.211 and 75.70 ±5.15mmHg respectively. Vitamin D2 in cases and controls came out to be 15.03 ±18.11 and 24.11 ±17.05 ng/ml respectively. A significant p value of <0.05 was obtained suggesting a likely correlation between hypertension and hypovitaminosis D. Pearson’s correlation for systolic BP was r =-0.175, p value =0.18. For diastolic BP, r =0.194, p = 0.05 (correlation was significant at level 0.05). OR was 5.053 revealing hypovitaminosis D to be a likely risk factor. Conclusion: Our results suggest that hypertension is likely to be correlated with hypovitaminosis D.

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