Shamaila Wadud, Muhammad Ahmad, Farzana Khan.
Relationship Of Glycemic Control With Thyroid Hormone Levels In Patients With Type 2 Diabetes Mellitus.
J Postgrad Med Inst Jan ;31(4):353-6.

Objective: To compare the results of thyroid function tests in euthyroid type 2 diabetic patients and normal healthy individuals on the basis of glycemic control. Methodology: This case control study of 300 subjects; 150 with type 2 diabetes and 150 controls, paired by age and gender, was conducted at two teaching hospitals of Peshawar during February-July 2013. They were sampled to investigate the relationship of thyroid hormones with glycemic profile determinants. Fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) were measured. The concentration of thyroid stimulating hormone (TSH), total triiodothyronine (TT3) and thyroxine (TT4) were evaluated using a Radioimmunoassay procedure. Diabetics were further divided into 2 groups on the basis of their good/poor glycemic control as shown by their HbA1c. P value of <0.05 was considered significant for comparison. Results: Serum concentration of TT3 and TT4 were significantly low and high, respectively, in diabetic group as compared with healthy controls on the basis of FPG and HbA1c (p <0.05). While comparing diabetics on the basis of glycemic control, both TT3 and TT4 were significantly low in the group with poor glycemic control (p <0.05). Diabetics with poor glycemic control had a raised mean TSH level (2.52 ±3.21) as compared with diabetics with good glycemic control (1.68 ±1.13) but the difference was not statistically significant. Conclusion: Patients with type 2 diabetes were associated with a low TT3 and a high TT4 level, respectively, as compared to their normal controls in euthyroid diabetic patients.

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