Faizania Shabbir, Shakir Khan, Muhammad Javad Yousaf, Muhammad Alamgir Khan, Tausif Ahmed Rajput.
Comparison of effect of High Fat Diet induced Obesity and Subsequenty atorvastatin Administration on Different Anthropometric Measure in Sprague Dawley Rats.
Pak Armed Forces Med J Jan ;66(5):699-704.

Objective: to compare the effect of high fat diet induced obesity and atorvastatin administration on different anthropometric parameters in Sprague Dawley rats. Study Design: Randomized control trial (RCT). Place and duration of study: the study was conducted at Department of Physiology, Army Medical College Rawalpindi in collaboration with National institute of Health (NIH) Islamabad and was completed in 12 months. Material and Methods: Ninety healthy Sprague Dawley rats were taken and divided into three equal groups with 30 rats in each group. Group I rats (normal control) were given normal diet for 3 weeks. Group II rats (obese control) were given high fat diet for 3 weeks. Group III rats (obese treated) were orally given 10mg/kg/day of atorvastatin through gavage method for 3 weeks after obesity induction. at the start of the study, initial body weight and naso-anal length of all the rats in each group were recorded and then weight change was regularly recorded thrice weekly. Naso-anal length was again recorded at the end of the experiment. Results: there was a significant increase in body weight in high fat diet induced obese and obese atorvastatin treated rats (p<0.05). No significant change in either body mass index or Lee index was observed in any of the groups. Conclusion: atorvastatin administration to high fat diet induced obese rats had no significant effect on any of the anthropometric measure of obesity.

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