Fatima Riaz, Kirn-e Muneera, Muhammad Adnan Saeed.
Effect of High Dose Ginger on Plasma Testosterone and Leutinising Hormone Levels in Male Rats after Lead Induced Toxicity.
J Rawal Med Coll Jan ;21(1):90-2.

Background: To study the effect of high dose ginger on plasma testosterone and leutinising hormone levels in male rats after lead induced toxicity Methods: In this quasi experimental study, 30 adult male Sprague Dawley rats were divided in two equal groups. Group A was given 0.3% lead acetate in drinking water and kept as lead control while the Group B was given a dose of 1.5gm/kg body weight ginger orally along with 0.3% lead for 42 consecutive days. Rats were then sacrificed and serum testosterone and LH levels were analyzed using ELISA technique. Data was expressed as mean±SD. P-values <0.05 were considered as statistically significant. Results: At the end of 42 days, mean serum testosterone level in Group A (control Group) was 2.2667± 0.45617ng/ml as compared to Group B (Experimental Group) 2.2667 ± 0.45617ng/ml and showed statistically insignificant change(p>0.05). Comparison of mean serum LH levels in Group A (5.3200 ± 0.72526ng/ml)revealed statistically insignificant difference (p>0.05) as compared to Group B (5.7467 ± 0.70190ng/ml). Conclusion: High dose ginger (>1gm/kg body weight) failed to enhance the suppressed testosterone level due to lead toxicity in male rats.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com