Parvez Mohmand, Hamid Hussain, Naeem Ullah.
Frequency of Subclinical Hypothyroidism in Adult Overweight and Obese Individuals in District Peshawar.
J Saidu Med Col Jan ;8(2):72-4.

Background: Overt hypothyroidism and its associated complications particularly weight gain and hypercholesterolemia are well established but association of the subclinical hypothyroidism to overweight, obesity and related comorbidities is controversial till date. Since routine screening for thyroid function is not in practice, in majority of symptomless patients subclinical hypothyroidism remain undiagnosed. Generally in obese patients with elevated serum cholesterol level subclinical hypothyroidism gets ignored as a component of etiological factors and remain undiagnosed. Presence of subclinical hypothyroidism in overweight and obese individuals has not been established as a cause or the result till date. Treatment of subclinical hypothyroidism with few exceptions is not indicated in routine practice. This study was aimed to look into an association of subclinical hypothyroidism with overweight and obesity and to provide a baseline observation for further longitudinal studies on the subject. Objective: To assess the correlation of thyroid hormones level (Thyroid stimulating hormone and free thyroxine) with overweight 2 and obesity among overweight and obese adults (BMI > 24.9 kg /m and age 18 50 years). Material & Methods: This cross-sectional study was conducted from April, 2015 to September, 2015 at the Chemical Pathology department of Khyber Medical College Peshawar. Participants who were willing to participate were screened for inclusion and exclusion criteria using a health check questionnaire and 200 eligible individuals were included in the study. Written informed consent was obtained from the selected participants. Results: Out of 200 analyzed participants 40 (20%) were females and 160 (80%) were males. Binary logistic regression analysis showed that median TSH levels were significantly associated with BMI. Conclusion: Our study suggests that obesity and overweight is associated with subclinical hypothyroidism however this is affected by other variables like age, gender and glycemic state of the person. This finding supports the idea that SCH may be the result rather than an etiological factor for obesity and overweight.

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