Mohammad Khalid Shaikh, Samiullah Shaikh, Jawed Samo, Ghulam Hussain Baloch, Muzafar Shaikh, Farhana Mangrio.
Association between Helicobacter Pylori Eradication and Weight Gain.
J Liaquat Uni Med Health Sci Jan ;15(01):21-5.

BACKGROUND: Helicobacter Pylori is a common infection highly prevalent globally causing chronic gastritis, duodenal ulcer and gastric carcinoma. It is observed clinically that patients who underwent therapy for eradication of H Pylori developed weight gain. Objective of this study was to evaluate the association between weight gain and eradication of H pylori infection. METHOD: For this observational cross sectional study, 137 patients were studied after confirmation of diagnosis of H pylori. Base line data at the beginning of the study and comparison between pre- treatment and post treatment outcomes were assessed after 3 months of follow up. RESULT: After eradication therapy, a difference in body weight was evident from pre-treatment mean body weight of 61.7±12.3 kg to 62.5±11.2 Kg (P=0.011). An increase in BMI was recorded from pretreatment BMI of 23.24 ±2.1Kg/m2 to 26.4±3.8 Kg/m2 (P=0.028). The assessment of symptoms was performed by applying Mann-Whitney U test of significance; score of symptoms showed a decline in intensity after eradication therapy. Mean score of dyspepsia decreased from 2.65 to 1.02 with a P value of 0.024, mean score of epigastric pain from 2.73 to 1.14(P=0.041), mean upper abdomen fullness from 2.49 to 0.35(P=0.021). A decrease in heart burn was noted 3.46 vs 0.92 (P=0.003) and loss of appetite was less severe; 2.89 vs 0.58 (P=0.011) CONCLUSION: The eradication of H Pylori, after 3 months of treatment, is associated with mild weight gain.

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